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Valtrex (valacyclovir) is a medicine used to keep the herpes infection under control preventing its outbreaks. Some of the medical conditions you have can interfere with the efficiency of your treatment. You need to mention to your doctor the fact of having kidney disease, a weak immune system, or HIV\AIDS. This medicine is not expected to affect the health of your unborn baby in any way, but you still need to tell your doctor if you are pregnant or breastfeeding before taking valacyclovir. Valtrex side effects include headache, stuffy nose, mild skin rash, mild skin rash, sore throat and joint pain.